Relying on large-eddy simulation (LES) and an efficient algorithm to track a huge number of Lagrangian particles through turbulent flow fields in general complex 3D domains, the flow in a pipe and a model combustion chamber is tackled. The influence of particle-fluid (two-way coupling) as well as particle-particle interactions (four-way coupling) is investigated. The latter is modeled based on deterministic collision detection. First, the LES results of a particle-laden vertical pipe flow with a specular wall and a mass loading of 110% are evaluated based on DNS data from the literature. Second, the predicted LES data of a ring combustion chamber at two different mass loadings (22% and 110%) are analyzed and compared with experimental measurements.