Simulation plays an essential role in modular mechanical and plant engineering. The required models are, like the real modules, provided by different manufacturers or company divisions. Especially with regards to virtual commissioning, but also in operation-parallel simulation, numerous module models from different sources must be gathered, coupled, and kept up-to-date. This paper presents a concept for reducing the associated manual activities based on an agent-based assistance system. The aim is to generate, configure and operate simulation models with the least possible effort. In this paper, the focus is on supporting the commissioning phase.