| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Dottermusch, Matthias | - |
| dc.contributor.author | Schumann, Yannis | - |
| dc.contributor.author | Kordes, Uwe | - |
| dc.contributor.author | Hasselblatt, Martin | - |
| dc.contributor.author | Neumann, Julia E. | - |
| dc.date.accessioned | 2022-02-21T12:10:19Z | - |
| dc.date.available | 2022-02-21T12:10:19Z | - |
| dc.date.issued | 2021-11-24 | - |
| dc.identifier.issn | 1365-2990 | - |
| dc.identifier.issn | 0305-1846 | - |
| dc.description.abstract | We performed spatial epigenetic and transcriptomic analyses of a highly unusual low-grade diffusely infiltrative tumour with INI1 deficiency (CNS LGDIT-INI1), which harboured a high-grade component corresponding to an atypical teratoid/rhabdoid tumour (AT/RT). Methylation profiles of both low-grade and high-grade components yielded high similarity with AT/RTs of the MYC subgroup, whereas RNA expression analyses revealed increased translational activity and MYC pathway activation in the high-grade component. Close follow-up of patients harbouring CNS LGDIT-INI1 is warranted. | - |
| dc.description.sponsorship | Erich und Gertrud Roggenbuck-Stiftung | - |
| dc.description.sponsorship | High Performance Computing | - |
| dc.language.iso | eng | - |
| dc.publisher | Wiley-Blackwell | - |
| dc.relation.ispartof | Neuropathology and Applied Neurobiology | - |
| dc.title | Spatial molecular profiling of a central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency featuring a high-grade atypical teratoid/rhabdoid tumour component | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.1111/nan.12777 | - |
| dc.identifier.pmid | 34820878 | - |
| dc.identifier.scopus | 2-s2.0-85120381111 | - |
| dcterms.bibliographicCitation.pagestart | 1 | - |
| dcterms.bibliographicCitation.pageend | 6 | - |
| dcterms.bibliographicCitation.originalpublisherplace | Oxford | - |
| local.submission.type | only-metadata | - |
| dc.type.article | Scientific Article | - |
| hsu.peerReviewed | ✅ | - |
| item.grantfulltext | none | - |
| item.languageiso639-1 | en | - |
| item.fulltext_s | No Fulltext | - |
| item.openairetype | Article | - |
| item.fulltext | No Fulltext | - |
| crisitem.author.dept | High Performance Computing | - |
| crisitem.author.parentorg | Fakultät für Maschinenbau und Bauingenieurwesen | - |
| Appears in Collections: | 3 - Publication references (without fulltext) | |
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