DC FieldValueLanguage
dc.contributor.authorDottermusch, Matthias-
dc.contributor.authorSchumann, Yannis-
dc.contributor.authorKordes, Uwe-
dc.contributor.authorHasselblatt, Martin-
dc.contributor.authorNeumann, Julia E.-
dc.date.accessioned2022-02-21T12:10:19Z-
dc.date.available2022-02-21T12:10:19Z-
dc.date.issued2021-11-24-
dc.identifier.issn03051846-
dc.description.abstractWe performed spatial epigenetic and transcriptomic analyses of a highly unusual low-grade diffusely infiltrative tumour with INI1 deficiency (CNS LGDIT-INI1), which harboured a high-grade component corresponding to an atypical teratoid/rhabdoid tumour (AT/RT). Methylation profiles of both low-grade and high-grade components yielded high similarity with AT/RTs of the MYC subgroup, whereas RNA expression analyses revealed increased translational activity and MYC pathway activation in the high-grade component. Close follow-up of patients harbouring CNS LGDIT-INI1 is warranted.de_DE
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG)de_DE
dc.description.sponsorshipErich und Gertrud Roggenbuck-Stiftungde_DE
dc.description.sponsorshipHigh Performance Computingde_DE
dc.language.isoende_DE
dc.publisherWiley-Blackwellde_DE
dc.relation.ispartofNeuropathology and Applied Neurobiologyde_DE
dc.subject.ddcDDC::000 Informatik, Informationswissenschaft, allgemeine Werkede_DE
dc.subject.ddcDDC::500 Naturwissenschaften und Mathematikde_DE
dc.titleSpatial molecular profiling of a central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency featuring a high-grade atypical teratoid/rhabdoid tumour componentde_DE
dc.typeArticlede_DE
dc.identifier.doi10.1111/nan.12777-
dc.identifier.pmid34820878-
dc.identifier.scopus2-s2.0-85120381111-
dcterms.bibliographicCitation.pagestart1de_DE
dcterms.bibliographicCitation.pageend6de_DE
dcterms.bibliographicCitation.originalpublisherplaceOxfordde_DE
dc.relation.pages6de_DE
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85120381111-
local.submission.typeonly-metadatade_DE
dc.identifier.eissn1365-2990-
dc.description.peerReviewedYesde_DE
dc.type.articleScientific Articlede_DE
item.grantfulltextnone-
item.fulltext_sNo Fulltext-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairetypeArticle-
crisitem.author.deptHigh Performance Computing-
crisitem.author.parentorgFakultät für Maschinenbau und Bauingenieurwesen-
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