Wireless communication systems are enabler technologies for modern and flexible production concepts, essentially within the Industry 4.0 directive. For reliable low-latency wireless communication, the availability of frequency spectrum is a general prerequisite. IO-Link Wireless (IOLW) is a vendor-independent wireless communication standard, which operates in the 2.4 GHz ISM (Industrial, Scientific, Medical) band and especially addresses the requirements of industrial discrete manufacturing processes. The 2.4 GHz ISM band is used by various other radio systems, making coexistence management a fundamental challenge. Blacklisting and frequency hopping schemes are specified to increase the IOLWcoexistence behavior. In this paper coexistence management methods and tools, which can be employed for IOLW are presented. These tools can be used to enhance the coexistence behavior and thus the reliability, and at the same time, reduce energy consumption. After an introduction and a detailed presentation of IOLW, a software tool is presented that allows to implement an intelligent frequency management by adapting blacklists to the respective coexistence and boundary conditions. This is based on generic measurements, which are also shown in this paper. Finally, a conclusion and an outlook for further integration into an overall system are given.