Publication:
“I was almost in disbelief” - qualitative analysis of experiences and expectations among psoriasis patients undergoing biologic treatment with secukinumab

cris.customurl16614
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cris.virtual.departmentKlinische Psychologie und Psychotherapie
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cris.virtual.departmentbrowseKlinische Psychologie und Psychotherapie
cris.virtual.departmentbrowseKlinische Psychologie und Psychotherapie
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cris.virtualsource.department8838d34d-9abf-4522-ab9c-24fea6d26097
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dc.contributor.authorHölsken, Stephanie
dc.contributor.authorBenthin, Carina
dc.contributor.authorKrefting, Frederik
dc.contributor.authorMühlhaus, Senta
dc.contributor.authorNestoriuc, Yvonne
dc.contributor.authorSchedlowski, Manfred
dc.contributor.authorSondermann, Wiebke
dc.date.issued2024-06-24
dc.description.abstractPsoriasis is a highly debilitating chronic inflammatory disease. Increased understanding of its pathophysiology has enabled development of targeted treatments such as biologics. Several medical treatments have been shown to be influenced by patients’ experiences and expectations. However, only little is known about patients’ experiences with and expectations towards biologics. Our objectives were to identify patients’ treatment experiences and treatment expectations and assess their trajectories over the course of treatment with the IL-17A inhibitor secukinumab. Moreover, we aimed to document effects of psoriasis, factors that influence symptomatology, and prior treatment experiences. Patients and Methods We conducted semi-structured interviews with n = 24 patients with moderate-to-severe plaque psoriasis and employed a qualitative content analysis to derive thematic and evaluative codes. Findings were validated via peer debriefings with experienced dermatologists. Results Patients reported burdensome physical and psychological psoriasis symptoms and identified factors that can improve or worsen symptomatology, including stress and self-efficacy. Prior treatment experiences were mostly negative. Past barriers to effective treatment included time constraints or limited access. Concerning secukinumab, patients initially expected complete to partial remission of symptoms and occurrence or absence of side effects. Closer inspection of expectations and experiences revealed three trajectories. For most patients, initial expectations were met and future expectations remained unchanged. For the other patients, however, the experience did not match their initial expectation. One group then adapted their future expectations according to their experience, while the other group did not. Conclusion To our knowledge, this is the first qualitative study to assess expectations towards treatment effectiveness and side effects, their trajectories, and interplay with experiences among psoriasis patients. Our findings highlight the value of further research on the subject in order to optimize care for psoriasis patients and to learn more about the trajectories and influence of treatment expectations in general.
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dc.identifier.citationNestoriuc Y, Schedlowski M, Sondermann W. "I Was Almost in Disbelief" - Qualitative Analysis of Experiences and Expectations Among Psoriasis Patients Undergoing Biologic Treatment with Secukinumab. Patient Prefer Adherence. 2024 Jun 24;18:1299-1310. doi: 10.2147/PPA.S458643. PMID: 38947870; PMCID: PMC11213235.
dc.identifier.doi10.2147/PPA.S458643
dc.identifier.issn1177-889X
dc.identifier.pmid38947870
dc.identifier.urihttps://openhsu.ub.hsu-hh.de/handle/10.24405/16614
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.journalPatient Preference and Adherence
dc.relation.orgunitKlinische Psychologie und Psychotherapie
dc.rights.accessRightsmetadata only access
dc.subjectDoctor-patient relationship
dc.subjectPatient perspective
dc.subjectPsychodermatology
dc.subjectSecukinumab
dc.subjectTreatment success
dc.subject.ddc150 Psychologie
dc.title“I was almost in disbelief” - qualitative analysis of experiences and expectations among psoriasis patients undergoing biologic treatment with secukinumab
dc.typeForschungsartikel
dspace.entity.typePublication
hsu.peerReviewed
hsu.uniBibliography
oaire.citation.endPage1310
oaire.citation.startPage1299
oaire.citation.volume18
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